Congenital Syphilis: Diagnosis and Treatment


Congenital syphilis, an insidious infection transmitted from mother to fetus during pregnancy, poses a significant health threat globally. Despite advancements in healthcare, cases of congenital syphilis persist, emphasizing the importance of understanding its clinical presentation, diagnosis, and management.

Hutchinson Teeth - Congenital syphilis

Case Presentation

A 28-year-old pregnant woman presented to the clinic with a history of untreated syphilis. Upon examination, she displayed no apparent symptoms. However, laboratory investigations revealed positive serological tests for syphilis. Further evaluation through ultrasound indicated fetal abnormalities consistent with congenital syphilis.

Signs and Symptoms

1. Hutchinson Triad

Congenital syphilis, resulting from the vertical transmission of Treponema pallidum from mother to fetus, manifests with a constellation of signs and symptoms, among which the Hutchinson triad holds particular diagnostic significance.

1. Hutchinson Teeth
A hallmark feature of congenital syphilis, Hutchinson teeth present as notched, widely spaced, and peg-shaped incisors. The characteristic screwdriver-like appearance of these teeth reflects the developmental disturbances affecting the dental enamel, providing clinicians with a valuable diagnostic clue during examination.

2. Interstitial Keratitis
Interstitial keratitis, inflammation of the corneal stroma, constitutes another component of the Hutchinson triad. Affected individuals may present with photophobia, tearing, and corneal opacities, leading to visual impairment if left untreated. The association between interstitial keratitis and congenital syphilis underscores the importance of ophthalmologic evaluation in affected infants.

3. Eighth Nerve Deafness
Eighth nerve deafness, or sensorineural hearing loss, completes the Hutchinson triad and represents a significant complication of congenital syphilis. The involvement of the auditory nerve can lead to varying degrees of hearing impairment, affecting language development and overall quality of life. Audiological assessments are essential for early detection and intervention to optimize auditory outcomes in affected infants.

In addition to the Hutchinson triad, congenital syphilis may present with a spectrum of other signs and symptoms, including rash, hepatosplenomegaly, skeletal abnormalities, and neurological complications. Prompt recognition and management of congenital syphilis are imperative to mitigate the long-term sequelae associated with this pernicious infection, emphasizing the critical role of healthcare providers in ensuring optimal maternal and neonatal outcomes.

Risk Factors :

Congenital syphilis, a preventable yet persistent health concern, is intricately linked to various maternal and healthcare-related risk factors that contribute to its transmission from mother to fetus during pregnancy.

1. Maternal Syphilis Infection

Untreated maternal syphilis during pregnancy stands as the primary risk factor for congenital syphilis. Mothers with active syphilis infections, particularly those in the primary and secondary stages, have a heightened risk of transmitting the bacterium Treponema pallidum to the fetus through the placenta, leading to congenital syphilis.

2. Inadequate Prenatal Care

Insufficient access to prenatal care, characterized by delayed initiation of antenatal visits or infrequent follow-up appointments, poses a significant risk for congenital syphilis. Missed opportunities for early screening, diagnosis, and treatment of maternal syphilis increase the likelihood of vertical transmission to the fetus, underscoring the importance of comprehensive prenatal care services.

3. Lack of Routine Screening

The absence of routine syphilis screening during pregnancy represents a critical gap in preventive healthcare measures. Failure to screen pregnant women for syphilis, especially in high-prevalence regions or vulnerable populations, hampers early detection and treatment of maternal infections, thereby heightening the risk of congenital syphilis transmission.

4. Untreated Sexual Partners

Maternal exposure to untreated sexual partners with syphilis contributes to the risk of congenital syphilis transmission. Inadequate partner notification, testing, and treatment further perpetuate the cycle of syphilis transmission within sexual networks, amplifying the risk of maternal-fetal transmission during pregnancy.

5. Socioeconomic Factors

Socioeconomic disparities, including poverty, lack of access to healthcare services, and inadequate health education, exacerbate the risk of congenital syphilis. Limited resources, transportation barriers, and social stigma surrounding sexually transmitted infections (STIs) may impede timely diagnosis and treatment, disproportionately affecting marginalized communities.

6. Geographic Prevalence

Regional variations in syphilis prevalence and healthcare infrastructure influence the risk of congenital syphilis. Areas with higher syphilis burden and suboptimal healthcare systems are more likely to experience increased rates of vertical transmission, highlighting the importance of targeted interventions and resources allocation.

• Differential Diagnosis

The clinical presentation of congenital syphilis overlaps with various other neonatal conditions, necessitating a comprehensive differential diagnosis. Conditions such as intrauterine infections, metabolic disorders, and congenital anomalies should be considered and ruled out through thorough evaluation and laboratory testing.

Laboratory Diagnosis Of Congenital syphilis:

The laboratory diagnosis of congenital syphilis entails a systematic approach involving serological tests, confirmatory assays, and ancillary investigations to facilitate accurate detection and management of the infection. Below, we delve into each aspect of laboratory diagnosis in detail.

1. Serological Tests
Serological testing serves as the cornerstone of diagnosing congenital syphilis, leveraging the detection of antibodies against Treponema pallidum in maternal and infant specimens. Two types of serological tests are commonly employed:

  • Non-treponemal Tests: Non-treponemal tests, such as the Venereal Disease Research Laboratory (VDRL) and Rapid Plasma Reagin (RPR) tests, detect antibodies that react with cardiolipin, a component of host cells damaged by T. pallidum. These tests provide qualitative and quantitative results, aiding in disease monitoring and treatment response assessment.
  • Treponemal Tests: Treponemal tests, including the Treponema pallidum particle agglutination assay (TPPA), fluorescent treponemal antibody absorption (FTA-ABS) test, and enzyme immunoassays (EIAs), detect specific antibodies targeting T. pallidum antigens. These tests offer high sensitivity and specificity, confirming the presence of syphilis infection.

2. Confirmatory Testing
Confirmatory testing is essential to validate the results obtained from initial serological assays, particularly in cases where discordant or equivocal findings arise. The following confirmatory tests are commonly employed:

  • FTA-ABS Test: The FTA-ABS test utilizes fluorescently labeled anti-human antibodies to detect antibodies bound to T. pallidum antigens, confirming the presence of syphilis infection. It is considered the gold standard confirmatory test due to its high specificity.
  • TPPA: Similar to the FTA-ABS test, TPPA detects specific antibodies against T. pallidum antigens but employs particle agglutination instead of fluorescence. TPPA serves as an alternative confirmatory assay with comparable performance to FTA-ABS.

3. Cerebrospinal Fluid (CSF) Analysis
In cases of suspected neurosyphilis or symptomatic central nervous system involvement, CSF analysis may be warranted to assess for the presence of T. pallidum. CSF examination typically involves the following parameters:

  • CSF VDRL Test: The CSF VDRL test detects antibodies against T. pallidum in the cerebrospinal fluid, indicating active infection within the central nervous system. Positive CSF VDRL findings necessitate prompt treatment and close neurological monitoring.
  • CSF Cell Count and Protein Analysis: Evaluation of CSF cell count and protein levels aids in assessing for the presence of inflammation and neuronal damage associated with neurosyphilis, guiding therapeutic decision-making and prognostication.


Early diagnosis and prompt treatment of congenital syphilis are crucial to prevent complications and adverse outcomes. The recommended treatment regimen involves administering intravenous penicillin G to both the mother and the infant, tailored based on the stage of syphilis and the presence of complications.


Untreated congenital syphilis can lead to severe complications, including but not limited to stillbirth, prematurity, neurodevelopmental deficits, and multiorgan dysfunction. Long-term sequelae may persist into adulthood, underscoring the importance of timely intervention and follow-up care.

In conclusion, congenital syphilis remains a significant public health concern, necessitating heightened awareness, routine screening, and timely intervention to mitigate its adverse effects. By understanding its clinical presentation, risk factors, and appropriate management strategies, healthcare providers can effectively combat the scourge of congenital syphilis and safeguard maternal and neonatal health.

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