Acetazolamide – Uses, mechanism and side effects
Acetazolamide: Mechanism of Action Acetazolamide is a sulfonamide derivative that noncompetitively and reversibly inhibits carbonic anhydrase (CAse type II) in proximal tubule (PT) cells. This inhibition slows the hydration of CO2, reducing the availability of bicarbonate (HCO3-) for exchange with luminal sodium. Effects on PT Cells Inhibition of brush border carbonic anhydrase (CAse type IV) […]
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