Combination Therapy: Spironolactone and ACE Inhibitors – Mechanism, Benefits, and Risks

IntroductionHeart failure and certain types of hypertension often require multiple medications to manage effectively. Among the therapeutic options, angiotensin-converting enzyme (ACE) inhibitors and spironolactone, a mineralocorticoid receptor antagonist, are frequently used. When combined, these two drug classes can offer synergistic…